Hypertension and ibuprofen: beware of drug interactions


According to work carried out last April by researchers from several countries (United States, Canada, Spain), patients taking treatment based on inhibitors of the renin-angiotensin system (ISRA) must pay attention to certain interactions medication, especially with ibuprofen.

Hypertension and heart failure: appropriate treatment

Patients with high blood pressure and/or heart failure are often prescribed treatment with inhibitors of the renin-angiotensin system (ISRA). These include Losartan® and aliskiren (Rasilez®). In addition to these drugs, patients are often required to take diuretics. This treatment is essential to regulate blood pressure in the short and long term.

Ibuprofen and ISRA: an increased risk of severe kidney problems

Canadian researchers from the University of Waterloo, authors of the recently published work, simulated on a computer the simultaneous intake of ibuprofen, drugs that inhibit the renin-angiotensin system (ISRA) and diuretics. Result ? Patients were at increased risk of severe kidney problems, in particular because of a phenomenon of dehydration. “Concomitant use of a diuretic, a renin-angiotensin system (RAS) inhibitor and a nonsteroidal anti-inflammatory drug (NSAID) significantly increases the risk of acute renal failure (ARF). This phenomenon is known as the “triple whammy”” can we read in the report. Thus, the scientists in charge of the study recommend that patients prefer taking paracetamol in case of pain rather than ibuprofen.

Ibuprofen: many contraindications

Ibuprofen belongs to the family of nonsteroidal anti-inflammatory drugs (NSAIDs). It works at three levels:

  • Analgesic for pain;
  • Antipyretic against fever;
  • Anti-inflammatory against inflammation.

Very common, it is found in pharmacies under different names: Advil®, Nurofen®, Spedifen®, Antaren®… These drugs are available without a prescription but are still safe. r. Moreover, NSAIDs are contraindicated for:

  • Pregnant women ;
  • In case of heart disease;
  • In case of liver disease;
  • In case of kidney disease;
  • History of bleeding, peptic ulcer disease;
  • In case of chickenpox;
  • If taking anticoagulant.

Ibuprofen has also been talked about in the midst of the Covid-19 pandemic. Indeed, according to the government website, “it seems that nonsteroidal anti-inflammatory drugs can be a factor in aggravating the infection. In the case of a COVID-19 infection, paracetamol is recommended.” If in doubt, it is better to seek advice from your general practitioner (general practitioner) or the advice of a pharmacist before taking anti-inflammatories. Generally, better to be careful in case of self-medication.

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